由Bifidobacterium adolescentis衍生而来的海帕福林通过促进肝脏Cry1表达来减轻乙氨基的肝毒性
Ping Qin1,2, Yanru Li3,4, Yangjing Su1
1Center for Drug Research and Development, Guangdong Provincial Key Laboratory of Advanced Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Journal of translational medicine
|May 31, 2024
概括
青少年双杆菌通过产生低素来预防乙氨基诱导的肝损伤 (AILI). 这种代谢物减少炎症和氧化应激,为AILI提供了潜在的治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
背景情况:
- 乙氨基 (APAP) 诱导的肝损伤 (AILI) 是一个重要的健康问题.
- 对于Bifidobacterium adolescentis (B. adolescentis) 对AILI的保护作用尚不清楚.
研究的目的:
- 研究B. adolescentis在预防AILI中的潜力.
- 阐明B.青少年介导保护的潜在机制.
主要方法:
- 使用了AILI的动物模型.
- 进行了生物化学分析,组织病理学和与酶相关的免疫吸收试验.
- 使用非向代谢学,体外培养和转录组分析.
主要成果:
- 在小鼠中,B. adolescentis显著减弱了AILI.
- B. adolescentis产生了代谢物海帕福林,该代谢物抑制了炎症和氧化应激.
- 低氨酸上调Cry1表达,减轻肝损伤;在人类AILI患者中观察到Cry1表达的降低.
结论:
- 青少年 B. 通过产生低氨酸来防止 AILI.
- 希帕福林通过上调Cry1来缓解肝损伤,减少炎症和氧化应激.
- 这项研究突出了使用B. adolescentis及其代谢物为AILI的新治疗方法.
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