一个有暴露史的第一民族社区中神经系统功能障碍症状的演变:一项纵向研究
Aline Philibert1, Judy Da Silva2, Myriam Fillion3
1Centre de recherche interdisciplinaire sur le bien-être, la santé, la société et l'environnement (CINBIOSE), Université du Québec À Montréal, CP 8888, Succ. Centreville, Montréal, Québec, H3C 3P8, Canada.
概括
长期暴露于继续导致Grassy Narrows第一民族的神经系统功能障碍,症状在五年内恶化. 这凸显了对医疗服务的持续需求,并表明对神经健康的逐渐影响.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 土著健康土著健康
背景情况:
- 自20世纪60年代以来,Asubpeeschoseewagong Anishinabek (Grassy Narrows First Nation) 领土上的 (Hg) 污染影响了社区的健康和传统.
- 尽管暴露量下降,但过去的长期暴露与晚年神经系统功能障碍集群有关.
研究的目的:
- 评估神经系统症状的流行和进展,在最初评估后五年.
- 检查长期,过去的暴露对这些症状及其进展的贡献.
主要方法:
- 在5年后 (第1次到第2次) 给85名成年人重新使用了症状问卷.
- 症状集群算法用于评估症状集群的变化.
- 纵向混合效应模型 (LMEM) 使用头发 (HHg) 测量 (1970-1997) 来评估与症状集群和子组进展的关联 (年龄>40y与≥10 HHg测量).
主要成果:
- 对于大多数症状,在时间1和时间2之间观察到症状频率和平均利克特得分的显著增加.
- 症状集群得分的增加与年龄或性别无关,除了年轻人的感觉障碍.
- 长期过去的暴露与大多数症状集群得分和它们随着时间的推移增加的速度在分析的子组中显著相关.
结论:
- 五年来症状的持续和增加频率强调了持续医疗保健服务的需要.
- 结果表明,对神经系统功能障碍的逐渐影响,特别是在40岁以上的个人中,具有历史暴露数据.
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