恶性病在中国的抗中性粒细胞抗体相关血管炎患者中增加
Xiang-Yu Han1, Zhi-Ying Li2, Ming-Hui Zhao1
1Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 100034, China.
Arthritis research & therapy
|June 1, 2024
概括
患有抗中性粒细胞质抗体 (ANCA) 相关血管炎 (AAV) 的中国患者面临恶性瘤的风险更高. 肺癌是最常见的,环胺的使用与长期AAV患者的风险增加有关.
科学领域:
- 类风湿病学 类风湿病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 西方患者患有抗中性粒细胞体抗体 (ANCA) 相关的血管炎 (AAV) 的癌症风险较高.
- 关于中国AAV患者恶性瘤发病率,谱和危险因素的数据有限.
研究的目的:
- 为了调查在被诊断患有AAV的中国患者中恶性瘤的发病率,频谱和危险因素.
- 为了将中国AAV患者的恶性瘤风险与普通人群进行比较.
主要方法:
- 在北京大学第一医院1995-2021年间诊断的552名AAV患者的回顾性分析.
- 计算标准化发病率 (SIR),根据年龄,性别和随访时间进行调整.
- 分析了包括性别,年龄和环胺剂量在内的危险因素.
主要成果:
- 与一般人群相比,AAV患者的恶性瘤风险显著增加 (SIR:2.24).
- 肺癌是最常见的恶性瘤,其次是脏,膀,尿道和前列腺癌.
- 男性性别,年龄较大和累计环胺剂量 (>20.0 g) 与恶性瘤风险增加有关,特别是在AAV诊断后的5年内.
结论:
- 与普通人群相比,中国AAV患者患恶性瘤的风险增加.
- 中国AAV患者的恶性瘤谱与西方患者不同.
- AAV本身和环胺治疗都可能导致恶性瘤风险升高.
更多相关视频
相关概念视频
Abnormal Proliferation
4.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K
Cytomegalovirus Disease
108
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
108


