无限内植物:它们作为抗真菌剂对抗首要病原体的作用
1Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, African Union Organization Street, Abbassia, Cairo, 11566, Egypt. ashaimaa_yehia@pharma.asu.edu.eg.
Microbial cell factories
|June 1, 2024
概括
多抗性真菌构成越来越大的威胁,治疗选择有限. 这篇评论探讨了300多种内菌化合物,突出了它们对抗Candida albicans和Aspergillus fumigatus等具有挑战性的真菌感染的潜力.
科学领域:
- 菌类学和制药科学 菌类学和制药科学
- 自然产品化学 自然产品化学
- 发现抗微生物药物 发现抗微生物药物
背景情况:
- 越来越多的抗药性真菌需要新的治疗药物.
- 现有的抗真菌药物类别 (多烯,醇等) 面临着新兴的抵抗.
- 菌类和人类之间的有限遗传差异使抗菌药物开发复杂化.
研究的目的:
- 批判性地分析具有抗真菌活性的内性化合物的化学性质,功效和来源.
- 从1980年至2024年审查从内细胞中分离出来的约320种抗真菌化合物,用于对抗关键的真菌病原体 (Candida albicans,C. auris,Cryptococcus neoformans,Aspergillus fumigatus).
- 识别新的抗真菌线索并了解结构-活性关系 (SAR).
主要方法:
- 对报告具有抗真菌活性的内性化合物研究的综合文献综述.
- 对特定真菌物种的化合物疗效的分析,包括最小抑制度 (MIC) 值.
- 对化合物的新性,化学特性和真菌起源的评估,重点是Eurotiales和Hypocreales等级.
主要成果:
- 总共测试了320种化合物;其中46%对Candida albicans活跃,23%对Cryptococcus neoformans活跃,29%对Aspergillus fumigatus活跃.
- 只有2%的化合物对Candida auris表现出活性,而素和鲁比基诺辛C是显著的例外.
- 同培养技术增强了对神秘代谢物的发现,Irperide显示出1μg/mL的强效MIC. 鲁比基诺辛C在抑制真菌生物膜方面表现出潜在的潜力.
结论:
- 内植物代表了新型抗真菌化合物的有希望的,未经探索的来源.
- 进一步开发培养技术和激活静态代谢途径对于发现新的抗真菌药物至关重要.
- 像鲁比基诺辛C这样的化合物为向反抗性真菌提供了新的途径,包括潜在的生物膜抑制策略.
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