慢性呼吸道疾病的表型与气道阻塞
T C Nguyen1, H V T Tran1, M H T Tran1
1Polyclinic, Department of Family Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
概括
一项新的策略简化了越南喘-COPD重叠 (ACO) 患者的分类. 皮肤刺痛测试,结核病史和症状发病年龄有助于区分ACO患者患有喘或COPD,指导治疗.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 临床免疫学临床免疫学
- 肺部病理学 肺部病理学
背景情况:
- 在越南,喘和慢性阻塞性肺病重叠 (ACO) 的高患病率需要简化患者分类.
- 目前全球喘倡议 (GINA) 和全球慢性阻塞性肺病倡议 (GOLD) 的指导方针要求对ACO患者进行简化应用.
- 区分喘,COPD和ACO对于有效的治疗策略至关重要.
研究的目的:
- 开发和验证一个简化的策略来对越南阻塞性肺病患者进行分类.
- 根据临床和诊断特征,区分喘类ACO (ACO-A) 和COPD类ACO (ACO-B).
- 为了使患者分类与GINA和GOLD治疗建议保持一致.
主要方法:
- 使用GINA/GOLD指南将235名肺功能阻塞患者分为COPD,喘或ACO类别.
- 假设的ACO-A会呈现出阳性皮肤刺探测试 (SPT) 或没有结核病 (TB) 史的早期症状发作.
- 假设的ACO-B将呈现出负的SPTs,晚期症状发作和/或结核病病史.
主要成果:
- 患病率:喘 (21%),ACO-A (22%),ACO-B (17%),COPD (40%) 等疾病的流行情况.
- ACO-A与过敏史,鼻炎和儿童喘有关.
- ACO-B与高累积吸烟相关;在各种参数中,在"所有喘"和"所有COPD"组之间发现了显著的差异.
结论:
- 喘-慢性阻塞性肺病重叠 (ACO) 患者可以有效地根据皮肤刺伤测试 (SPT),结核病 (TB) 史和症状发病年龄进行分类.
- 这种分类策略有助于将ACO患者定义为主要患有喘或COPD.
- 这些发现支持在临床实践中简化管理ACO的方法.
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