在具有普遍BCG疫苗接种政策的国家中,儿童结核病的结果
J V Dias1, L Varandas2, L Gonçalves3
1Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Department of Paediatrics, Hospital Beatriz Ângelo, Loures.
概括
儿童结核病 (TB) 的结局仍然令人担忧,不良结局率为19.5%,死亡率为6.1%. 有针对性的卫生政策对于改善儿童结核病患者治疗结果至关重要.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 显著影响儿童发病率和死亡率.
- 低诊断和有限的数据掩盖了儿童结核病的真正负担.
- 现有的数据低估了儿童结核病的影响.
研究的目的:
- 系统地审查和描述儿童结核病治疗结果.
- 提供有关儿科结核病结果的最新流行病学数据.
- 为打击儿童结核病的公共卫生战略提供信息.
主要方法:
- 对2000年至2020年间发表的研究进行系统审查.
- 包括在普遍BCG疫苗接种的国家对儿童 (0-14岁) 的研究.
- 随机效应元分析,以综合治疗结果数据.
主要成果:
- 从1,806个引用中,包括了35篇文章.
- 总体不利结果比例为19.5%;综合病例死亡率为6.1%.
- 在较小的儿童 (0-4岁:6.6%) 和结核病/艾滋病毒同时感染的儿童 (15.1%) 中,病例死亡率较高.
结论:
- 儿童结核病治疗结果仍然是一个重大的全球健康问题.
- 需要加强对弱势儿科群体的努力和有针对性的卫生政策.
- 解决数据缺口对于有效管理和减少全球儿童结核病负担至关重要.
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