生大粉在诱导糖尿病的老鼠中的治疗效果
Ambreen Qadir1, Faiza Anwar1, Habib Ur Rehman1
1Department of Allied Health Sciences, The Superior University, Lahore, Rahim Yar Khan Campus, Pakistan.
Pakistan journal of pharmaceutical sciences
|June 1, 2024
概括
生和大补充剂显著改善了老鼠的2型糖尿病. 这些天然疗法降低了血糖,改善了关键健康标志物,表明糖尿病并发症风险降低.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 2型糖尿病是一个全球性的健康问题,其特点是高血糖和胰岛素抵抗.
- 目前用于2型糖尿病的治疗方法可能会产生副作用和不同的疗效.
- 像生 (Zingiber officinale) 和大 (Allium sativum) 这样的天然化合物传统上用于各种健康益处.
研究的目的:
- 在2型糖尿病的小鼠模型中研究生和大的低血糖作用.
- 评估生和大单独或组合对关键代谢参数的影响.
- 评估这些天然补充剂在缓解糖尿病并发症方面的潜力.
主要方法:
- 四十五只雄性白色大鼠被诱导患有2型糖尿病,使用了链毒素.
- 鼠被分为五组:正常控制,糖尿病控制,生,大和生+大.
- 动物接受了两个月的生和/或大粉,治疗后分析了各种血液和组织标记物.
主要成果:
- 与糖尿病控制组相比,补充生和/或大显著降低了禁食血糖,糖化血红蛋白,总胆固醇和低密度脂蛋白水平.
- 血清胰岛素和高密度脂蛋白水平在治疗组显著增加.
- 所有治疗组的肝糖原水平显示在统计学上显著增加.
结论:
- 生和大粉在2型糖尿病大鼠中显示出显著的低血糖效应.
- 和大的联合使用可能为治疗2型糖尿病提供协同效益.
- 这些发现表明,生和大可能是管理2型糖尿病和减少相关并发症的有价值的辅助剂.
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