治疗耐药抑郁症的老年人使用酒精和物质
Maytinee Srifuengfung1,2, Eric J Lenze1, Steven P Roose3
1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
International journal of geriatric psychiatry
|June 1, 2024
概括
一半患有治疗耐药抑郁症 (TRD) 的老年人使用酒精,通常与其他物质一起使用. 在抗抑郁药物治疗期间同时使用酒精和其他物质可能会增加跌倒风险,需要进一步调查.
科学领域:
- 老年精神病学是一门精神病学专业.
- 临床药理学 临床药理学
- 药物中毒药物 药物中毒药物
背景情况:
- 老年人中,酒精和物质的使用正在增加,特别是那些患有抑郁症的人.
- 患有抑郁症的老年人同时使用物质会带来独特的治疗挑战和潜在的危险.
- 在老年人群中,耐治疗抑郁症 (TRD) 需要仔细考虑同时使用物质.
研究的目的:
- 为了调查TRD诊断的老年人的酒精和其他物质使用模式.
- 为了确定患者的特征与较高的酒精消费相关的这一群体.
- 检查酒精使用如何缓和临床因素和抗抑郁药物治疗期间跌倒事件之间的关系.
主要方法:
- 从TRD的老年人OPTIMUM随机抗抑郁药试验的基线数据的二次分析.
- 多变量顺序逻辑回归用于识别较高酒精使用的预测因素.
- 相互作用建模,以评估酒精在抗抑郁药治疗期间对跌倒的缓解作用.
主要成果:
- 51%的参与者报告使用酒精,10%是危险饮酒者,41%的低风险.
- 在21%的饮酒者中观察到同时使用二.
- 其他物质的使用 (例如大麻) 与酒精消费水平相增加 (5%的戒断者,9%的低风险者,15%的危险者).
- 其他物质使用预测只有在非饮酒者中增加跌倒风险.
结论:
- 大约一半的TRD老年人承认饮酒.
- 在这个群体中,同时使用酒精和二类药物和其他物质很普遍.
- 在抗抑郁药物治疗期间,与酒精和其他物质联合使用相关的风险,包括跌倒,需要进一步研究.
关键词:
老化的老化 衰老的老化大麻大麻大麻大麻大麻大麻大麻大麻抑郁症 抑郁症是一种抑郁症.年长的老人老年人老年人.布布布的情况大型抑郁症主要是抑郁症.大麻大麻大麻大麻是什么意思聚物质是一种多元物质.年长的老年人,老年人.治疗耐药性抑郁症 治疗耐药性抑郁症更多相关视频
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