精神分裂症的起源:一个起源故事
Rebecca Birnbaum1, Daniel R Weinberger1
1Departments of Psychiatry, Genetics, and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York (Birnbaum); Lieber Institute of Brain Development, Maltz Research Laboratory, and Departments of Psychiatry, Neurology, Neuroscience, and Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore (Weinberger).
精神分裂症是一种神经发育障碍,其中遗传风险会影响早期大脑发育. 在精神病发作之前早期预测和干预可能会提供更好的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症被归类为神经发育障碍,但其与大脑发育的联系仍然不清楚.
- 典型的诊断发生在成年早期,提出了关于发育起源的问题.
研究的目的:
- 重新检查精神分裂症的神经发育模型.
- 整合最近的基因组,转录,表观基因组和细胞数据.
主要方法:
- 对大规模精神分裂症遗传关联研究的分析.
- 对人类死后大脑的转录和表观基因组数据的检查.
- 使用神经发育的细胞模型.
主要成果:
- 精神分裂症遗传风险在早期大脑发育阶段趋同.
- 遗传风险的影响是动态的,取决于环境,并且在空间和时间上有所变化.
- 规范性神经发育的乱与精神分裂症有关.
结论:
- 精神分裂症的生物学基础在于早期的神经发育障碍.
- 治疗策略应利用遗传风险标志物进行早期预测.
- 专注于产前和产周预防与精神分裂症的发育轨迹保持一致.
更多相关视频
05:51A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
08:04Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
Published on: November 19, 2020
相关概念视频
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Psychological and Sociocultural Causes of Schizophrenia
Schizophrenia
Positive Symptoms Schizophrenia: Hallucinations and Delusions
Hallucinations
Hallucinations in...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
