在化学发光测试中分析干扰测量了 ангиотензин I, ангиотензин II,阿尔多斯特和雷宁
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Xiaohua Xu1, Yongzhi Xu1, Shengqiang Liang1
1Department of Clinical Laboratory, The 909th Hospital, School of Medicine, Xiamen University, Zhangzhou, Fujian, China.
Journal of clinical laboratory analysis
|June 1, 2024
概括
斯皮罗诺拉克显著干扰阿尔多的免疫测试,但其他测试物质在血管素I,血管素II和素的测试中显示出可接受的干扰.
科学领域:
- 临床化学 临床化学
- 实验室医学 实验室医学
- 免疫测试开发 免疫测试的发展
背景情况:
- 由于干扰,可能会产生实验室错误,这可能会影响免疫检测结果的准确性.
- 针对血管新生素I,血管新生素II,阿尔多和雷宁等关键激素的免疫检测对这种干扰很容易受到干扰.
- 了解干扰对于可靠的诊断测试至关重要.
研究的目的:
- 评估内源和外源物质对免疫试验的体外干扰.
- 评估各种物质对抗胰岛素I,抗胰岛素II,阿尔多斯特和雷宁测量准确性的影响.
- 确定这些关键激素测定中的临床显著干扰.
主要方法:
- 使用超生理学/超治疗水平进行查研究,以确定潜在的干扰物.
- 用最大病理/治疗度进行剂量反应研究以量化偏差.
- 基于对干扰Ang I,Ang II,阿尔多斯特和雷宁试验的预设接受标准进行评估.
主要成果:
- 多种物质显示出对Ang I,Ang II和Renin测试的潜在干扰.
- Спиронолактон,瓦尔萨坦,葡萄糖,胆固醇,血红蛋白和甘油三是被确定的潜在干扰剂之一.
- 在阿尔多斯素免疫测试中,只有螺旋乳显示出临床显著的干扰 (超过±10.0%偏差).
结论:
- 外源性螺旋乳是阿尔多素免疫试验中的一个显著干扰剂.
- 对于Ang I,Ang II和Renin测定,其他评估物质的干扰被认为是可以接受的.
- 确保试验特异性和尽量减少干扰对于准确的激素水平测定至关重要.
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