外周炎症标志物的动态变化与疾病严重程度有关,并预测了肌痛性硬化症的短期不良后果
Yiyun Weng1, Jinrong Zhu1,2, Shengqi Li1,3
1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Journal of neurochemistry
|June 1, 2024
概括
像NLR,PLR和AISI这样的外周炎症标志物与肌痛性骨髓灰质炎 (MG) 的严重程度相关. 这些标志物的动态变化,特别是AISI,可以预测MG患者的短期不良结果.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 临床医学 临床医学
背景情况:
- 外周炎症标志物与肌痛性骨髓灰质炎 (MG) 严重程度之间的联系,以及它们对患者结果的预测潜力,仍然不清楚.
- 现有研究尚未完全确定炎症标志物的动态变化对预测MG的短期结果的有用性.
研究的目的:
- 调查外围炎症标志物及其动态变化与美国梅毒严重症基金会 (MGFA) 分类之间的关联.
- 用这些炎症标志物预测MG患者的短期不良结果.
主要方法:
- 对154名MG患者的回顾性研究 (2016年6月 - 2021年12月).
- 后勤回归分析以评估标记者-MGFA分类关系并确定预测因素.
- 用于结果预测的诺摩图构造,使用净重新分类改进 (NRI) 和综合歧视改进 (IDI) 进行验证.
主要成果:
- 中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和系统性炎症总指数 (AISI) 与MGFA分类有显著的关联.
- 在NLR,全身免疫炎症指数 (SII) 和AISI的动态变化改善了疾病严重程度的歧视.
- AISI与短期不良结果有显著的关联;一个预测模型实现了0.953.95的AUC.
结论:
- 周围炎症标志物与MG疾病严重程度有显著的关联.
- 作为一个易于获得的预测生物标志物,AISI显示出在MG患者中短期不良结果的前景.
- 动态评估炎症标志物可以提高MG严重程度和患者结果的预测.
相关概念视频
Myasthenia Gravis: Diagnostic Tests
767
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
767
Myasthenia Gravis: Overview and Treatment
1.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
77
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
77


