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桃体切除术后出血和止痛药使用之前和之后,FDA对代代因进行了警告
Chloe Cottone1, Arunima Vijay2, Anjalika Chalamgari2
1Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, New York, U.S.A.
The Laryngoscope
|June 1, 2024
概括
随着2013年FDA的警告,小儿桃体切除术后的止痛药的使用已经从可代因转移. 这一变化与桃体切除术后出血事件的轻微但显著增加相关.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 疼痛管理 疼痛管理
- 药物监督 药物监督 药物监督
背景情况:
- 2013年美国食品和药物管理局 (FDA) 的盒装警告建议儿童桃体切除术患者不要使用代因.
- 了解止痛趋势和警告后出血发生率对于患者安全至关重要.
研究的目的:
- 为了分析小儿桃体切除术后止痛药利用的变化.
- 评估2013年FDA警告之前和之后的桃体切除术后出血的发生率.
主要方法:
- 使用 TriNetX 美国协作网络 (2008-2022) 的回顾性研究.
- 确定了15648542名年龄在18岁以下的患者.
- 分析了止痛药的使用 (可代因,易布洛芬,乙氨基,氧可,凯托洛拉克,可) 和出血率.
主要成果:
- 2013年之后,桃体切除术后出血的发生率从1.8%增加到2.4% (p=0.029).
- 可代因的使用量显著下降 (10.4%至0.5%),而易布洛芬,乙氨基,凯托洛拉克和氧可的使用量增加.
- 没有观察到可使用的变化.
结论:
- 自2013年FDA警告以来,小儿桃体切除术后止痛药的处方模式发生了重大变化.
- 桃体切除术后出血的统计显著增加与这些止痛药转换同时发生.
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