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在激光切除术后的无症状间隔,用于复发性异常性亚囊狭窄症
Katherine Z Xie1, Andrew J Bowen2, Thomas J O'Byrne3
1Department of Otolaryngology-Head & Neck Surgery, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA.
概括
针对异常性亚结节狭窄症的激光切除术后的无症状间隔随着每次复发而缩短. 没有先前手术的患者比先前扩张的患者有更长的无症状期.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 呼吸道外科手术 呼吸道外科手术
- 儿科手术 儿科手术
背景情况:
- 复发性异常性下狭窄症 (iSGS) 构成一个重大管理挑战.
- 激光切除术 (LWE) 是iSGS的一种治疗选择.
- 了解无症状间隔对于管理iSGS至关重要.
研究的目的:
- 分析iSGS的LWE后无症状间隔的持续时间.
- 评估影响这些间隔的因素,包括患者病史和疾病特征.
主要方法:
- 在第三级中心对210名接受LWE (2002-2021) 的iSGS患者进行了回顾性审查.
- 根据之前的呼吸道手术,患者被归类为LWE初级 (LWEP) 或LWE二级 (LWES).
- 条件脆弱重复事件模型用于分析中位时间到复发 (MTR).
主要成果:
- 没有症状的间隔随着每次随后的复发显著缩短.
- 复发的中位时间 (MTR) 从第一个LWE后的4.1年指数级下降到第12次复发后的0.7年.
- 在前6次复发中,LWEP患者的MTR比LWES患者更长.
结论:
- 对于iSGS,LWE后的无症状间隔随着复发率的增加而减少.
- 最初的手术史 (LWEP与LWES) 影响了无症状间隔的持续时间,特别是在早期.
- 疾病和患者因素与第一次复发后的术间间间隔没有显著的相关性.
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