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Updated: Jun 24, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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基于多聚乙烯的肠肝芯片用于评估药物的第一通代谢和口服生物可用性

Mengyang Wang1, Yuko Sasaki2, Rena Sakagami1

  • 1Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.

ACS biomaterials science & engineering
|June 1, 2024
PubMed
概括

这项研究引入了一种新的肠肝芯片系统,使用聚来改善口服药物吸收研究. 该系统准确地评估了第一通代谢和生物可用性,优于传统模型.

关键词:
在Caco-2细胞中.生物可用性 生物可用性共同培养是一种共同文化.第一次通过新陈代谢.在芯片上的肠肝人类肝细胞肝细胞.

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