在摄入糖后,在底侧杏仁体内注入 scopolamine 诱导了老鼠有条件的味道回避
Víctor Manuel Torres-García1, Emmanuel Rodríguez-Nava1,2, Rosa Itzel Alcántara-Rivas1
1Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.
Psychopharmacology
|June 1, 2024
概括
在品尝了一种新鲜的味道后,在底侧杏仁体 (BLA) 中阻断肌酸受体会导致老鼠持续避免这种味道. 这表明肌肉蛋白受体活性在味道学习和记忆中起着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 学习和记忆的学习和记忆
背景情况:
- 基底侧杏仁体 (BLA) 中的肌肉蛋白受体活性与情感学习和可塑性有关.
- BLA在减轻新恐惧症 (AN) 中发挥着作用,这一过程中,新鲜的口味变得熟悉并被认为是安全的.
研究的目的:
- 调查肌肉蛋白受体活性在BLA中的作用在偶然的味道学习中.
- 为了确定肌糖类抗体对口味厌恶和偏好的影响.
主要方法:
- 带有BLA小枪的老鼠接受了载体或肌肉抗剂.
- 反对药物在新品味之前,消费后立即,或在检索会话后被管理.
- 使用了特定的 (M1,M3,M2) 和非特定的 (scopolamine) 肌肉抗剂.
主要成果:
- 在新鲜的味道呈现之前,BLA内部的斯科波拉明取消了新恐惧症 (AN) 的减弱.
- 味道消费后的斯科波胺给药诱导了持续的味道回避,不依赖于新性或可将其推广到其他味道.
- M1和M3对抗剂导致部分味道回避,而M2对抗剂没有影响.
结论:
- 在突出口味体验后,BLA中的肌肉受体对抗导致强烈和持久的味道回避.
- 斯科波胺的认知效应取决于情境,超越记忆丧失,受到特定的大脑结构和相关任务的影响.
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