评估克洛皮多格雷尔,高凝结率和血小板计数在狗进行脊髓切除术的脊髓质量
Guk-Il Joung1, Jeong-Yeol Bae1, Jung-Il Kim1
1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea.
The veterinary quarterly
|June 1, 2024
概括
克洛皮多格雷尔可以预防狗的脊髓切除术后血栓细胞瘤和高凝血能力. 这项研究发现,与未接受治疗的狗相比,在脊髓切除术后用克洛皮多格雷尔治疗的狗的血小板数量较低.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 心血管科学 心血管科学
- 在瘤学瘤学.
背景情况:
- 狗的脊髓切除使它们易患致命的血栓状况.
- 血栓细胞瘤是脊髓切除术后高凝血能力的重要危险因素.
- 目前的兽医缺乏针对脊髓切除术后高凝血性的具体治疗方法.
研究的目的:
- 评估克洛皮多格雷尔对术后高凝血能力的预防作用.
- 评估克洛皮多格雷尔对进行缩切除术的狗的血栓塞瘤的影响.
- 为了确定在脊髓切除术后的前两个星期的疗效.
主要方法:
- 一项涉及12只经过脊髓切除术的狗的研究.
- 组A (n=7) 没有接受任何治疗;组B (n=5) 接受了克洛皮多格雷尔 (10 mg/kg的充满剂量,然后是2 mg/kg).
- 在手术前和手术后 (第2,7,14天) 分析了血液样本和血栓结晶学 (TEG).
主要成果:
- 组A在第7天和第14天显示出血小板数显著升高.
- 与基线相比,B组在第7天血小板升高,但在第14天没有升高.
- 14日血小板计数在B组明显低于A组;TEG参数显示相关性.
结论:
- 克洛皮多格雷尔的使用可能会减轻狗的脊髓切除术后血栓细胞瘤.
- 研究结果表明,克洛皮多格雷尔可以降低脊髓质块的脊髓切除术后的高凝血能力.
- 需要进一步的研究来证实克洛皮多格雷尔在这些病例中的治疗作用.
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