基于呈现的药物和动脉瘤破裂的"风险":纠正记录
Samer S Hoz1, Joseph S Hudson1, Li Ma1
1Department of Neurological Surgery, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
World neurosurgery
|June 1, 2024
概括
在呈现时使用药物并不表明由于呈现偏差而导致动脉瘤破裂的风险. 许多药物与未破裂的动脉瘤有关,而不是破裂保护.
科学领域:
- 神经外科 神经外科
- 临床药理学 临床药理学
- 流行病学 流行病学
背景情况:
- 以药物为基础评估动脉瘤破裂风险的回顾性研究可能会出现呈现偏差.
- 药物使用与动脉瘤呈现 (破裂与未破裂) 之间的关联需要仔细解释.
研究的目的:
- 在将药物使用与动脉瘤破裂风险联系在一起的研究中调查潜在的呈现偏差.
- 为了比较患有破裂与未破裂的内动脉瘤的患者的药物治疗情况.
主要方法:
- 一个对1311名治疗内动脉瘤的患者的回顾性图表审查 (2016年6月 - 2023年7月).
- 对人口统计,临床特征 (断裂状态) 和药物在呈现时的比较分析.
主要成果:
- 68%的破裂动脉瘤患者没有服用药物,而22%的未破裂动脉瘤患者 (P < 0.001).
- 51%的未破裂患者服用2-5种药物,而破裂患者则为15% (P < 0.001).
- 35种药物与未破裂的呈现有关;没有一种与破裂有关.
结论:
- 在呈现时使用药物并不表明动脉瘤破裂风险.
- 35种药物与未破裂呈现的确定的关联并不意味着有保护作用.
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