COVID-19中的肺中介:多中心病例控制研究中的风险因素和结果
Stefano Negri1, Emilia Mazzuca2, Filippo Lococo3
1Department of Pulmonology, Sant'Anna Hospital of Como, Italy.
Respiratory medicine
|June 1, 2024
概括
在COVID-19肺炎中,肺中介性肺炎与广泛的肺损伤,低BMI,高炎症和吸烟有关. 这种并发症导致更长的住院时间,增加输管率和更高的死亡率.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 在住院治疗2019年新冠肺炎 (COVID-19) 肺炎的患者中观察到肺中介肺炎的发病率增加.
- 肺中症是一种严重的并发症,可能会影响患者的治疗结果.
研究的目的:
- 为了识别与COVID-19相关的肺中关联的风险因素.
- 为了研究肺中介对COVID-19患者临床结果的影响.
主要方法:
- 进行了一项多中心追溯病例控制研究.
- 患有COVID-19肺炎和肺中的患者与没有肺中的对照组进行了比较.
- 风险因素使用多变量物流分析进行评估.
主要成果:
- 分析了139名带有肺中介药的患者和153名对照患者.
- 风险因素包括广泛的肺部参与 (≥75%),整合,低BMI (<22 kg/m2),高CRP (>150 mg/L),高D-二次数 (>3000 ng/mL FEUs) 和吸烟史 (>20包年).
- 肺中症患者的住院时间较长 (31.2 vs 19.6 天),输管率较高 (52.5% vs 17.6%),并增加了住院死亡率 (48.9% vs 23.5%).
结论:
- 广泛的肺膜干扰,巩固,低BMI,高炎症标志物和烟草暴露与COVID-19肺炎中肺中风险增加有关.
- 肺中症显著恶化临床结果,包括长时间住院治疗,更需要机械通风和增加死亡率.
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