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Updated: Jun 24, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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通过纳米体结合,对GPCR配体具有高度偏差的激进作用

Shivani Sachdev1, Brendan A Creemer1, Thomas J Gardella2

  • 1Laboratory of Bioorganic Chemistry, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bathesda, MD, USA.

Nature communications
|June 1, 2024
PubMed
概括

研究人员开发了一种新的方法来制造G蛋白结合受体 (GPCRs) 的途径选择性激动剂. 这种方法对甲状腺激素受体1 (PTHR1) 产生偏向的激素,为药物开发提供了新的策略.

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