胃食道逆流病和非酒精性脂肪肝疾病:两个样本的门德尔随机化结合元分析
Xuan Leng1,2, Wan-Zhe Liao3, Fen-Ping Zheng4
1Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, 310000, Zhejiang Province, China.
Scientific reports
|June 1, 2024
概括
胃食道逆流性疾病 (GERD) 可能因果性地增加患非酒精性脂肪肝疾病 (NAFLD) 的风险. 这项门德尔随机化研究证实了GERD和NAFLD之间存在显著的因果关系,突出了潜在的共同病因因素.
科学领域:
- 胃肠病学和肝病学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,胃食道逆流性疾病 (GERD) 和非酒精性脂肪肝疾病 (NAFLD) 之间存在关联.
- 观察性研究容易产生偏见,因此需要强大的方法来推断因果关系.
研究的目的:
- 使用孟德尔随机化 (MR) 调查GERD和NAFLD之间的潜在因果关系.
- 利用遗传变异作为工具变量来减少混和反向因果关系.
主要方法:
- 利用全基因组关联研究 (GWAS) 的GERD (暴露) 数据和FinnGen数据集的NAFLD (结果).
- 采用了各种MR方法,包括逆方差加权 (IVW),MR-Egger和加权中位数.
- 使用MR-Egger拦截测试,Cochran的Q测试,离开一个的分析,MR-PRESSO和Steiger方向性测试来评估发现的稳定性.
- 进行了元分析,以对因果效应进行整体评估.
主要成果:
- 门德尔的随机分析显示,GERD对NAFLD具有显著的因果关系.
- 整体因果估计表明,在患有GERD的个体中,NAFLD的几率增加 (OR 1.71,95% CI 1.40-2.09,P < 0.0001).
- 稳定性测试证实了确定的因果关系的有效性.
结论:
- 这项研究提供了强有力的遗传证据,证明GERD和NAFLD之间存在因果关系.
- 研究结果表明,GERD可能是NAFLD发展的风险因素.
- 对共享机制和临床影响的进一步研究是有必要的.
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