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化物和儿童智商:缺乏因果关系的证据
Deborah Moore1, Anne-Marie Glenny2
1Senior Clinical Lecturer / Honorary Consultant in Dental Public Health, The University of Liverpool, Liverpool, UK. Deborah.moore@liverpool.ac.uk.
Evidence-based dentistry
|June 1, 2024
概括
这次审查发现有强有力的证据表明,饮用水中的化物与牙化和儿童智商下降有关. 这些健康结果是确定水中化物安全水平的关键.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 饮用水中的化物对于牙健康是常见的.
- 确定安全水平需要了解健康影响.
- 之前的审查存在,需要更新的研究.
研究的目的:
- 确定评估与饮用水中的化物相关的健康结果的研究.
- 为了确定饮用水中化物的最大安全水平.
- 为了更新2016年澳大利亚评论的新研究.
主要方法:
- 在多个数据库和灰色文献来源中进行全面的文献搜索 (2016-2021年,到2023年2月为IQ和牙化补充搜索).
- 包括人类,动物和体外研究,检查与水化物相关的任何健康结果.
- 使用OHAT工具提取数据和评估偏差风险,然后进行叙事综合.
主要成果:
- 包括89个人类,199个动物和10个体外研究.
- 强有力的证据表明,在化物度<20 ppm的情况下,牙化和儿童智商下降的因果关系.
- 甲状腺功能障碍的证据中等,功能障碍的证据微弱,性激素干扰的证据有限.
结论:
- 牙化和儿童智商下降是确定安全饮用水化物水平的关键结果.
- 在较低度下,智商降低和剂量反应的机制尚不清楚.
- 需要进行进一步的研究,以确定饮用水中化物的明确上限安全值.
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