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Updated: Jun 24, 2025

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基于线粒体RNA修饰的签名来预测较低等级质瘤的预后:一个多omics探索和验证研究

Xingwang Zhou1, Yuanguo Ling1, Junshuan Cui1

  • 1Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, People's Republic of China.

Scientific reports
|June 1, 2024
PubMed
概括

线粒体RNA修饰 (MRM) 在低级质瘤 (LGGs) 中至关重要. 一个新的MRM得分预测了预后和治疗反应,为LGG提供了潜在的治疗点.

关键词:
大量RNA-seq分析表观遗传修饰是一种表观遗传修饰.较低级别的质瘤线粒体RNA的修饰一个单细胞分析.

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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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