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Updated: Jun 24, 2025

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

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DYNLL1通过ILF2/CDK4轴加速细胞循环,促进肝细胞癌的发展和palbociclib敏感度

Yuechen Liu1,2, Zhenkang Li1,2, Jinchao Zhang1,2

  • 1Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.

British journal of cancer
|June 1, 2024
PubMed
概括

氨酸轻链1 (DYNLL1) 通过激活ILF2/CDK4通路来驱动肝细胞癌 (HCC). 用palbociclib准CDK4/6,特别是与sorafenib结合使用,对治疗DYNLL1-过度表达的HCC有很大的希望.

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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

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Inhibition of Cdk Activity

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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