构建具有滑和抗粘性质的Zwitterionic涂层,用于隐形调整器应用
Rufang Wei1,2,3, Junjie Deng1,2,3, Xiangshu Guo1,2,4
1Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China.
Macromolecular rapid communications
|June 2, 2024
概括
隐形对齐器的新涂层可以减少斑块和口腔刺激. 水友性聚硫甲酸 (polySBMA) 涂层提高了对齐器的性能和口腔健康.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 矯正牙科 矯正牙科是一種矯正牙科.
背景情况:
- 隐形对齐器被广泛使用,但会导致斑块形成和口腔粘膜磨损.
- 这些问题可能导致复杂的口腔疾病,需要改进对齐器材料.
研究的目的:
- 在聚乙烯二甲基醇 (PETG) 调整器材料上开发水友性聚硫乙烯甲基酸盐 (polySBMA) 涂层.
- 赋予滑,防和抗粘性质,以提高对齐器的性能和口腔健康.
主要方法:
- 使用"移植到" (G-co-S) 和"移植到" (G-g-S) 的方法,采用了糖甲酸盐 (GMA) 辅助的涂层策略.
- 对涂层PETG表面的摩擦系数,蛋白质吸附,细菌粘附和生物膜形成进行了评估.
- 进行了体外生物相容性和体外口腔粘膜刺激测试.
主要成果:
- 两种G-co-S和G-g-S涂层都显著降低了PETG表面的摩擦系数.
- 在涂层表面上,蛋白质吸附,细菌粘附和生物膜形成被实质性地抑制.
- 涂层保持了2周的稳定性,并且表现出良好的生物相容性和无口腔刺激 in vivo.
结论:
- 开发的polySBMA涂层为提高隐形对齐器性能提供了一个有希望的策略.
- 这些涂层可以减轻斑块形成和口腔磨损等问题,有利于口腔健康治疗.
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