在初级活体供体肝移植后患有胆道缩的儿童的认知功能
Tingge Wang1, Yan Hu1, Zhanzhan Zhang1
1Department of Child Health Care, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China.
BMC pediatrics
|June 2, 2024
概括
经过肝移植 (LT) 的胆道缩 (BA) 的儿童表现出发育迟缓. 重复手术和营养问题会对这些年轻患者的认知发展产生负面影响.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 肝病学 肝病学是一种肝病学.
- 发育儿科 发育儿科
背景情况:
- 胆道形 (BA) 存活率改善了肝移植 (LT) 后的存活率,增加了对生活质量的关注.
- 调查婴儿的认知发育与BA后初级活体供体LT (BA-pLDLT) 是至关重要的.
研究的目的:
- 评估BA-pLDLT后的BA儿童的认知发展.
- 为了确定影响这一群体认知功能的因素.
主要方法:
- 在pLDLT后6个月招募了57名患有BA的儿童.
- 收集人口和临床数据;使用格里菲斯精神发展量表 (GMDS-C) 评估认知能力.
- 采用多变量线性回归来分析影响因素.
主要成果:
- 患有BA-pLDLT的儿童表现出明显较低的一般发育系数和特定域系数 (运动,语言等). 与 GMDS-C 规范相比.
- 28.07%的人有边缘发育迟缓,5.26%的人有发育迟缓,19.29%的人有语言迟缓.
- 对并发症的重新手术是总和运动系数下降的危险因素;较低的ZW与运动系数下降相关.
结论:
- 患有BA-pLDLT的儿童在生命早期经历发育迟缓.
- 重生和营养不足会对这些孩子的认知发展产生不利影响.
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