风湿性关节炎患者动脉硬度变化相关的因素:联合心脏研究
Anja Linde1,2, Eva Gerdts1,3, Bjørg T Fevang4
1Department of Clinical Science, Centre for Research on Cardiac Disease in Women, University of Bergen, Bergen, Norway.
Blood pressure
|June 2, 2024
概括
风湿性关节炎患者经历了增加的动脉硬度,尽管治疗. 管理心血管风险因素,如血压和糖尿病,与疾病修饰性抗风湿药物治疗 (DMARD) 一起至关重要,以保护动脉健康.
科学领域:
- 心血管健康 心血管健康
- 类风湿病学 类风湿病学
- 血管生物学 血管生物学
背景情况:
- 风湿性关节炎 (RA) 不成比例地影响女性,与高血压和动脉硬有关.
- 在接受治疗的RA患者中,了解影响动脉硬的因素对于心血管风险管理至关重要.
研究的目的:
- 为了研究与风湿性关节炎患者接受疾病修饰性抗风湿药物 (DMARD) 治疗中动脉硬性变化的相关因素.
主要方法:
- 77名RA门诊患者在基线和平均22个月后被评估脉冲波速度 (PWV),增压 (AP),增量指数 (AIx) 和疾病活动评分 (DAS28).
- 参与者被指示进行生物或有针对性的合成DMARDs治疗.
主要成果:
- 从基线到随访期间,平均PWV显著增加 (p < 0.001),尽管73%的患者实现了缓解或低疾病活性.
- 增加的PWV与更高的基线静脉血压,糖尿病,DAS28和身体质量指数 (BMI) 相关.
- 女性性别与更高的AP和AIx有关,但在随访时PWV较低,独立于混因素.
结论:
- 尽管接受了DMARD治疗,但患有较高基线疾病活性,BMI,糖尿病和缩血压升高的RA患者表现出更大的动脉硬性.
- 对心血管风险因素的有效管理对于保护RA患者的动脉功能至关重要,补充了减少炎症负荷.
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