瘤炎症微环境对切除的上升阶段腺癌生存的贡献
Alessandro Bonis1, Vincenzo Verzeletti1, Francesca Lunardi2
1Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy.
概括
通过PD-L1表达和瘤透性淋巴细胞 (TILs) 表示的瘤炎症微环境 (TIME) 影响了切除肺腺癌的存活率. 时间活跃患者的整体存活率 (OS) 比负时间状态患者更好.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胸部外科手术 胸部外科手术
背景情况:
- 瘤炎症微环境 (TIME) 影响癌症的发展和免疫规避.
- 免疫治疗的进步刺激了对TIME在非小细胞肺癌 (NSCLC) 中的作用的研究.
- 了解TIME对切除肺腺癌的生存的影响至关重要.
研究的目的:
- 研究TIME的独立作用,特别是PD-L1表达和瘤透淋巴细胞 (TILs),对整体存活率 (OS) 的独立作用.
- 分析 TIME 在切除,病理上升的肺腺癌 (ADC) 的预后价值.
- 从生存分析中排除混的术后变量.
主要方法:
- 对50名可切除肺部ADC的患者进行了回顾性研究.
- 患者经历了手术 (腹腔切除术或细分切除术),有意想不到的病理升级 (IIB或更高).
- 通过PD-L1表达和TILs数量 (>10%) 评估了TIME状态.
主要成果:
- 生存率与从IIB到IIIB阶段的微观变量增加没有显著的相关性.
- 具有TIME活性状态的患者 (阳性PD-L1和/或TILs>10%) 的生存状况明显优于双阴性患者 (PD-L1-/TILs-) (p=0.01).
- 与双阴性对应物相比,患有IIB阶段或更高ADC的时间活跃患者的生存率有所改善.
结论:
- 时间似乎是切除,升级的肺腺癌生存的独立预后因素.
- 这些发现支持将TIME评估整合到预测肺癌患者的结果中.
- 时间对生存的影响甚至在考虑其他病理变量时也很明显.
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