训练免疫力:风险因素与心血管疾病之间的联系
Mingqi Chen1,2, Xuya Kang1,2, Yan Zhang1,2
1Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
British journal of pharmacology
|June 2, 2024
概括
训练有素的先天免疫 (TRIM) 可能将生活方式因素与心血管疾病联系起来. 这篇评论探讨了TRIM.
科学领域:
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 炎症是心血管疾病发展的关键因素.
- 人们越来越认识到生活方式因素对心血管疾病风险的长期影响.
研究的目的:
- 审查训练天生的免疫力 (TRIM) 在心血管疾病中的作用.
- 探索TRIM作为生活方式因素和心血管疾病之间的潜在调解者.
- 确定与TRIM相关的心血管疾病的新机制和治疗点.
主要方法:
- 关于受过训练的先天免疫和心血管疾病研究的文献综述.
- 对将生活方式因素,TRIM和心血管疾病联系在一起的拟议机制的分析.
- 对TRIM参与心血管病理生理学的现有证据的综合分析.
主要成果:
- 训练有素的先天免疫 (TRIM) 涉及先天免疫细胞的持续功能变化.
- 假设TRIM能够调节生活方式因素 (压力,饮食,不活动) 对心血管疾病风险的长期影响.
- 有证据表明,TRIM在基础心血管疾病的炎症过程中起作用.
结论:
- 训练有素的天生的免疫力是心血管疾病的重要新兴因素.
- 了解TRIM为我们提供了关于早期生活事件和生活方式如何影响长期心血管健康的新见解.
- TRIM是开发心血管疾病新型治疗策略的一个有前途的领域.
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