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基于基因素乙化修饰模式的米费林向SLC9A9是高恶性胃癌的潜在治疗选择
Deng Guang1, Zhang Xiaofei1, Meng Yu1
1Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
Biochemical pharmacology
|June 2, 2024
概括
波米费林是一种天然化合物,向SLC9A9,通过禁用EGFR/PI3K/AKT通路来抑制胃癌 (GC) 的进展. 这项研究确定了SLC9A9作为预后生物标志物和pomiferin作为GC的潜在治疗剂.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 基素乙化变化与胃癌 (GC) 的进展有关.
- 波米费林在GC中确切的作用和分子点尚不清楚.
研究的目的:
- 建立基于基因组乙化调节器的GC预后风险模型.
- 为了研究米费林在GC中的瘤抑制机制.
- 确定潜在的治疗点和用于GC治疗的药物.
主要方法:
- 用于预后基因查的单变体和多变体考克斯回归分析.
- 最小绝对收缩和选择运算符 (LASSO) 考克斯回归用于风险模型构建.
- 分子对接,体外/体内实验,西式涂抹,免疫光和qPCR来评估波米费林的作用和机制.
主要成果:
- 建立了一个预后风险模型,确定溶解物载体家族9成员A9 (SLC9A9) 作为与GC中的基因素乙化相关的显著风险因素.
- SLC9A9的表达与异常的瘤免疫微环境相关.
- 波米费林与SLC9A9具有很高的结合亲和力,抑制了GC细胞恶性病变,并禁用了EGFR/PI3K/AKT信号通路.
结论:
- SLC9A9是一种致癌因子,也是GC中异常基因素乙化指标.
- 波米费林通过与SLC9A9结合并抑制EGFR/PI3K/AKT通路而产生抗瘤作用.
- 波米费林作为治疗高度恶性GC的治疗药物具有前景.
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