使用PEGylated超氧化物溶解溶解微针贴片的PEGylated超氧化物溶解酶高效预防辐射皮肤炎
Zhenchao Ma1, Yingrong Chen1, Kaixian Tang1
1Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou 313000, Zhejiang, China; Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou 313000, Zhejiang, China.
概括
溶解装有PEG-SOD的微针贴片显著改善了皮肤透,为预防辐射性皮肤炎提供了一种新的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 皮肤病学 皮肤病学
- 辐射保护剂 辐射保护剂
背景情况:
- 基化超氧化脱酶 (PEG-SOD) 是放射治疗中使用的一种细胞保护剂.
- 它在预防辐射性皮肤炎方面的有效性受到皮肤透性差的限制.
研究的目的:
- 开发一个装有PEG-SOD的溶解微针 (PSMN) 贴片,以加强预防辐射性皮肤炎.
- 评估PSMN贴片的皮肤透,辐射保护作用和愈合加速.
主要方法:
- 采用模板模具方法制造PSMN贴片,使用聚烯酸化K90.0.
- 评估了药物释放,皮肤透和in silico/in vivo药理动力学.
- 在受辐射影响的皮肤组织中评估了辐射保护活性和皮肤愈合效应.
主要成果:
- PSMN补丁显示了足够的机械强度,可以透到角层.
- 超过90%的PEG-SOD在30分钟内释放出来.
- 与PEG-SOD溶液相比,PSMN贴片的皮肤透率增加了500倍.
- PSMN贴片显著减轻了辐射引起的皮肤损伤和加速愈合.
- 观察到皮肤DNA的有效辐射保护活性.
结论:
- PSMN贴片显著增强PEG-SOD的皮肤透和吸收.
- PSMN贴片是预防辐射皮肤炎和保护皮肤免受辐射损伤的有希望的局部疗法.
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