空气污染,遗传因素和慢性鼻炎:英国生物银行的一项前性研究
Qinfeng Zhou1, Junxiong Ma1, Shyam Biswal2
1Department of Global Health, The Peking University School of Public Health, Beijing, China.
The Science of the total environment
|June 2, 2024
概括
长期暴露于空气污染会显著增加患慢性鼻炎 (CRS) 的风险,特别是带鼻息肉的亚型 (CRSwNP). 遗传倾向没有改变这种关联,强调了清洁空气对呼吸系统健康的重要性.
科学领域:
- 环境健康 环境健康
- 呼吸系统医学 呼吸系统医学
- 遗传学 是一个遗传学.
背景情况:
- 慢性鼻炎 (CRS) 是一种常见的呼吸道疾病,有以下亚型:带鼻息肉的CRS (CRSwNP) 和没有鼻息肉的CRS (CRSsNP).
- 以前的研究表明,空气污染和CRS之间存在联系,但遗传因素的影响尚未得到充分理解.
- 本研究调查了空气污染暴露和遗传敏感性对CRS发展的综合影响.
研究的目的:
- 检查环境空气污染物的长期暴露与CRS,CRSwNP和CRSsNP的发病率之间的关联.
- 评估通过多基因风险评分 (PRS) 评估的遗传倾向是否会改变空气污染和CRS之间的关系.
- 确定空气污染和遗传风险对CRS发展的独立和联合影响.
主要方法:
- 一项大型的英国生物银行队列研究与367298名参与者从2006年到2021年进行了跟踪.
- 空气污染水平 (PM2.5,PM10,NO2,NOx) 用参与者的住所的土地利用回归模型进行估计.
- 考克斯的比例危险模型和多基因风险评分被用来分析关联和基因环境相互作用.
主要成果:
- 长期暴露于PM2.5,PM10,NO2和NOx与CRS的风险增加有关.
- 对于CRSwNP来说,风险上升更为明显,尽管在统计学上并不显著.
- 较高的多基因风险得分加上空气污染的增加显示了CRS和CRSwNP的风险增加,但没有发现显著的相互作用.
结论:
- 长期暴露于常见的空气污染物是发展慢性鼻炎的重要危险因素.
- 这些发现强调了减少空气污染的公共卫生重要性,以减轻CRS发生率,特别是CRSwNP.
- 虽然遗传倾向在CRS中起作用,但它似乎与该队列中的空气污染暴露没有相互作用.
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