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在COVID-19的非常老的幸存者中长期死亡率
Christine Serratrice1, Michèle Jean2, François Herrmann3
1Division of Internal Medicine for the Aged, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
概括
在最初的COVID-19住院治疗中幸存下来的老年人在18个月内没有经历过多的死亡率. 然而,养老院居民面临的死亡率明显更高,这表明需要有针对性的支持.
科学领域:
- 老年医学 老年医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 第一次COVID-19浪潮不成比例地影响了老年人.
- 老年COVID-19幸存者的长期结果仍然是研究的关键领域.
- 了解出院后的死亡率对于老年护理至关重要.
研究的目的:
- 确定那些在COVID-19的急性阶段幸存下来的老年患者的18个月死亡率.
- 为了确定与这一队列中死亡率相关的风险因素.
- 评估生活状况对长期生存的影响.
主要方法:
- 进行了一项观察性队列研究.
- 包括的患者年龄在65岁或以上,并在第一波期间因COVID-19住院治疗.
- 统计分析包括费舍尔精确,曼·惠特尼U,t测试和考克斯比例危险回归.
主要成果:
- 在入院的323名患者中,有196人经过了急性阶段;34人 (17.3%) 在出院后18个月内死亡.
- 养老院住院 (HR 3.07,P = .007) 和重新住院与增加的死亡率有显著的关联.
- 根据年龄,性别,呼吸障碍或痴呆症,没有观察到生存率的显著差异.
结论:
- 与基线预期相比,18个月后,老年COVID-19幸存者没有表现出过度死亡率.
- 在养老院生活是COVID-19后住院生存率下降的重要独立风险因素.
- 调查结果强调了机构住院老年人的脆弱性,以及需要针对性地制定出院后护理策略.
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