在药剂师主导的诊所中,用于二次预防血管和糖尿病足患者的脂质降低优化
Matthew Hart1, Jon Rees2, Julia L Newton3
1Pharmacy, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, NE7 7DN, UK (Dr Hart).
Journal of clinical lipidology
|June 2, 2024
概括
药剂师主导的诊所显著改善了动脉样硬化疾病高风险患者的降脂疗法. 这种干预优化了他类药物的使用,并增加了实现脂质目标的患者数量,增强了心血管疾病的预防.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 在血管或糖尿病足部诊所的患者往往患有动脉样硬化疾病,心血管疾病 (CVD) 的风险很高.
- 这些患者需要高强度的脂质修饰疗法进行二次预防,但在初级保健中经常治疗不足.
- 社会贫困会加剧在治疗诸如动脉样硬化等慢性疾病方面的健康差异.
研究的目的:
- 为了评估药剂师领导的脂质优化诊所的有效性.
- 评估高风险患者对降脂疗法的影响,特别是他类药物的使用.
- 确定干预措施是否有助于在社会贫困程度较高的地区更好地实现脂质目标.
主要方法:
- 进行了一项临床队列研究.
- 药剂师主导的干预侧重于优化他类药物治疗和启动额外的降脂药物.
- 监测血液脂质概况进行,以评估治疗的有效性.
主要成果:
- 最初,81%的患者的非高密度脂蛋白 (非HDL) 胆固醇高于97mg/dL的目标值.
- 经过药剂师的干预,实现非HDL胆固醇目标的患者比例从19%增加到67%.
- 高强度他类药物的使用显著增加,低密度脂蛋白胆固醇水平显示平均减少.
结论:
- 一个由药剂师领导的服务有效地改善了高强度他类药物和其他降脂疗法的利用.
- 该干预措施在临床上具有挑战性的患者中,在实现脂质目标方面取得了显著的改善.
- 这种模型证明了在患有动脉样硬化疾病的贫困人口中管理脂质水平的成功.
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