细菌尿和表型抗微生物敏感性测试在45分钟内通过点护理Sysmex PA-100系统:第一次临床评估
Carles Alonso-Tarrés1,2, Carla Benjumea Moreno3, Ferran Navarro4,5
1Microbiology Laboratory, Fundació Puigvert, C/Cartagena 340-350, Barcelona, Spain. carlesmicro@gmail.com.
概括
赛斯麦克斯PA-100分析仪提供尿路感染 (UTI) 和抗菌感应性测试 (AST) 的快速结果,直接从尿液中获取. 这种点照顾系统可以帮助指导更快,更有效的抗生素治疗尿路感染患者.
科学领域:
- 临床微生物学 临床微生物学
- 护理点诊断的诊断方法
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 尿路感染 (UTI) 很常见,通常需要及时进行抗微生物敏感性测试 (AST) 才能有效治疗.
- 目前用于尿路感染诊断和AST的方法可能耗时,可能导致延迟或不适当的抗生素使用.
研究的目的:
- 评估新的Sysmex PA-100 AST系统的性能,用于检测尿路感染并从尿样直接执行AST.
- 将Sysmex PA-100的结果与标准微生物学方法进行比较.
主要方法:
- 分析了278名疑似无并发性尿路感染的女性患者的本源尿样.
- 赛斯麦克斯PA-100用于快速检测细菌尿和AST.
- 参考方法包括尿液培养以检测细菌性尿和AST的圆盘扩散.
主要成果:
- 赛斯麦克斯PA-100在15分钟内提供了细菌病的结果,在45分钟内提供了AST结果.
- 检测常见的尿路感染病原体的灵敏度和特异性很高 (例如,84.0%的灵敏度,99.4%的特异性).
- 对AST的总体分类一致性为85.4%至96.4%的测试抗微生物药物,使得78.4%的病例能够提供最佳治疗建议.
结论:
- 赛斯麦克斯PA-100提供快速的表型AST结果,方便及时启动针对性抗生素治疗尿路感染.
- 这种点诊系统有可能减少在患有尿路感染症状的患者处方无效或不必要的抗生素.
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