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肝硬化,代谢功能障碍和死亡风险:来自跨国前性队列研究的发现
Ana-Lucia Mayén1, Mirna Sabra1, Elom K Aglago2
1Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), 25 Avenue Tony Garnier, Lyon, 69007, France.
BMC medicine
|June 2, 2024
概括
非酒精性脂肪性肝病 (NAFLD) 和代谢综合征 (MetS) 会增加死亡风险. 患有肝硬化或代谢功能障碍的人面临更高的整体和特定原因死亡率,这凸显了干预的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 和代谢综合征 (MetS) 是非传染性疾病的重要贡献者.
- 了解它们对死亡率的影响对于公共卫生战略至关重要.
研究的目的:
- 调查NAFLD和METS与整体和因特定死亡率之间的关联.
- 评估新兴的分类,如代谢功能障碍相关的脂肪肝病 (MAFLD),代谢功能障碍相关的脂肪性肝病 (MASLD) 和代谢和酒精相关的肝病 (MetALD).
主要方法:
- 利用了EPIC队列中的15,784名参与者的数据,包括饮食,生活方式,人体识别和生物标志物信息.
- 评估NAFLD使用脂肪肝指数 (FLI) 和MetS使用修订后的定义.
- 采用多变量Cox比例危险模型来确定死亡终点的危险比率 (HR) 和95%置信区间 (95%CI).
主要成果:
- 高FLI (≥60) 与总死亡率 (HR=1.44) 和癌症 (HR=1.32),心血管疾病 (HR=2.06) 和其他原因 (HR=1.21) 的死亡率增加有关.
- MAFLD,MASLD和MetALD与整体死亡风险增加有关.
- MetS增加了所有死亡终点的风险,除了癌症特异性死亡率.
结论:
- 肝硬化和代谢功能障碍与明显更高的整体和因果特定的死亡风险有关.
- 这些发现强调了管理NAFLD和MetS对于降低长期死亡率的重要性.
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