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Updated: Jun 24, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
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Published on: April 9, 2018

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核友性芳香替代异烯化物与硫醇的替代

Weiqi Liu1, Xinghao Jin2, Dawei Ma2

  • 1Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Lu, Hefei 230026, China.

The Journal of organic chemistry
|June 3, 2024
PubMed
概括

这项研究引入了一种简单的核芳香替代 (SNAr) 方法来合成 heteroaryl thioethers. 在温和条件下,该反应与各种异二化物和硫醇一起运作良好,为有价值的化合物提供了一条多功能途径.

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Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
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In an electrophilic aromatic substitution reaction, an electrophile substitutes for a hydrogen of an aromatic compound.
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