在euthymic双极性障碍中,后侧环膜和中间前额外刺激-抑制平衡
Huai-Hsuan Tseng1,2,3, Cheng Ying Wu2, Hui Hua Chang4,5,6,7
1Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Psychological medicine
|June 3, 2024
概括
优性双极性障碍患者在默认模式网络枢纽中显示出改变的兴奋/抑制神经递质平衡. 这种不平衡,特别是在后带带状回形中,可能会导致双相情感障碍的认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 双极性障碍 (BD) 与持续的认知缺陷和功能障碍有关,即使是在euthymic阶段.
- 默认模式网络 (DMN) 功能障碍与 BD 有关,影响自我参考和情绪处理.
研究的目的:
- 为了研究 DMN 中枢内的刺激性 (谷氨酸/谷氨胺 - Glx) 和抑制性 (胺黄油酸 - GABA) 神经递质在安乐死性 BD 患者中的平衡.
- 为了探索神经递质平衡和认知功能之间的关系在euthymic BD.
主要方法:
- 质子磁共振光谱 (1H-MRS) 用于测量中部前额叶皮质/前带膜皮质 (mPFC/ACC) 和后带膜 (PCC) 中的Glx和GABA水平.
- 激发性/抑制性 (E/I) 的比率是使用 Glx 和 GABA 度来计算的.
- 认知功能,包括执行和注意力功能,使用标准化测试进行评估.
主要成果:
- 与健康对照组相比,Euthymic BD患者的注意力功能较差.
- 在euthymic BD患者的PCC中观察到显著更高的E/I比率,主要是由于 Glx水平升高.
- 在BD组中发现了mPFC E/I比率与执行职能之间的负相关性趋势.
结论:
- 尤提米性BD的特点是DMN枢纽中的E/I平衡受到干扰,特别是PCC中的Glx/GABA比率升高.
- 在DMN枢纽内的E/I平衡可以作为euthymic BD.的潜在生物标志物.
- 在DMN枢纽中改变的E / I平衡可能会导致在euthymic BD患者中观察到的执行功能缺陷.
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