如何在控制COVID-19流行病的努力中留下免疫受损的主机?
Michael Boeckh1,2, Steven A Pergam1,2, Ajit P Limaye2
1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
概括
免疫功能低下的人被排除在关键的COVID-19治疗试验之外. 未来的流行病准备需要为这个弱势群体提供专门的临床试验基础设施.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 临床研究 临床研究
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 流行病不成比例地影响了免疫力低下的个体.
- 这种脆弱的人群在很大程度上被排除在疫苗,单克隆抗体和小分子抗病毒药物的临床试验之外.
- 尽管治疗发展迅速,但从一开始就没有优先考虑医疗复杂和免疫受损个体的需求.
研究的目的:
- 突出在流行病准备中对包容性临床试验设计的关键需求.
- 倡导为免疫受损人群建立专门的临床试验基础设施.
- 在未来的健康危机期间,确保平等地获得拯救生命的治疗方法.
主要方法:
- 这项研究是基于在SARS-CoV-2大流行期间对临床试验参与的分析的透视作品.
- 它审查了从关键治疗试验中排除免疫受损个体的情况.
- 它主张积极规划和投资于专门的研究基础设施.
主要成果:
- 免疫功能低下的个体在获得基于证据的COVID-19治疗方面面临着显著的差异.
- 将这些人群排除在试验之外,代表了开发有针对性和有效的干预措施的错失机会.
- 目前的流行病准备战略缺乏足够的医疗复杂性和免疫受损群体的规定.
结论:
- 建立专门用于免疫受损人群的临床试验基础设施是至关重要的.
- 积极投资研究基础设施对于未来的流行病准备是必不可少的.
- 确保弱势群体被纳入早期研究是全球卫生公平的关键.
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