[一个基于voxel的磁共振研究皮质灰色物质结构在间歇性外热态]
1Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China.
概括
间歇性外热症 (IXT) 与大脑视觉处理区域的灰质体积减少有关. 这种降低与外热性严重程度增加和立体急性降低相关.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
背景情况:
- 间歇性外向性 (IXT) 是一种常见的偏形式,其特点是眼睛向外转动.
- 了解IXT的神经解剖学基础对于开发有效的治疗策略至关重要.
研究的目的:
- 用基于voxel的形态测量来研究IXT患者大脑皮层灰质体积变化.
- 分析这些结构性大脑变化与IXT的临床表现之间的相关性,例如外热性严重程度和立体急性.
主要方法:
- 一项横截面研究,比较了15名接受IXT治疗的患者和10名健康对照.
- 所有参与者都进行了磁共振成像 (MRI) 扫描.
- 使用SPM软件的基于voxel的形态测量 (VBM) 用于分析不同组之间的灰质体积差异.
主要成果:
- 患有IXT的患者在包括中枢大脑半球子,左舌环,左皮 V3区域,右额叶,左海马环和双侧侧核在内的区域显著减少灰质体积.
- 在IXT患者的双边尾状核和左前中心环中观察到灰质体积增加.
- 特定区域的灰质体积减少 (左侧,左侧骨角 V3,左侧舌环) 与外向性严重程度有负相关性.
- 在左和右额叶的灰质体积减少与立体急性负相关.
结论:
- 在IXT患者中,大脑区域的灰质体积减少,这些区域涉及V1和V2初级视觉皮层之间的水平视觉连接.
- 在舌环和背视觉通路V3区域灰色物质体积减少的程度与外向性变异的严重程度有关.
- 在IXT患者中,立体急性恶化与前中心 (BA6区域) 的灰质体积减少有关.
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