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Updated: Jun 24, 2025

RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
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解锁细胞可塑性:通过抑制原体和细胞外矩阵基因表达调节增强人类iPSC重编程

Jun Yang1, H Karimi Kinyamu1, James M Ward2

  • 1Chromatin and Gene Expression Section, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.

Stem cells (Dayton, Ohio)
|June 3, 2024
PubMed
概括

通过促进细胞可塑性和介质细胞-上皮细胞过渡,PFI-3增强诱导的多能干细胞 (iPSC) 重编程. 这种小分子抑制剂减少了细胞外矩阵基因表达,提高了iPSC生成效率.

关键词:
在MET中,MET是MET.在PFI-3中,PFI-3是最重要的.在 SWI/SNF 中.基胺抑制剂 基胺抑制剂细胞的可塑性 细胞的可塑性细胞外矩阵是细胞外矩阵.这就是 iPSC 的意义.重编程效率的效率是如何实现的

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