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Updated: May 12, 2026

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模拟部分自我补充的DNA四聚体的热阶段行为

Silvia Cristofaro1, Lara Querciagrossa2,1, Lorenzo Soprani1

  • 1Dipartimento di Chimica Industriale "Toso Montanari", Università di Bologna, Viale del Risorgimento 4, Bologna 40136, Italy.

Biomacromolecules
|June 3, 2024
PubMed
概括

短的DNA链自组装成液晶相. 分子动力学模拟准确地预测了DNA四重体的相位行为和聚合,揭示了合作组装成更大的结构.

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相关概念视频

Translesion DNA Polymerases02:10

Translesion DNA Polymerases

Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...