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Updated: Jun 24, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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多瘤病毒ALTOs,但不是MTs,通过激活NF-κB通路来降低病毒早期基因表达的调节

Nicholas J H Salisbury1, Supriya Amonkar1, Joselyn Landazuri Vinueza1,2

  • 1Fred Hutchinson Cancer Center, Pathogen-Associated Malignancies Integrated Research Center, Seattle, WA, 98109 USA.

bioRxiv : the preprint server for biology
|June 3, 2024
PubMed
概括

默克尔细胞多瘤病毒替代LT ORFs (ALTOs) 通过激活NF-κB信号和降低病毒转录来作为瘤抑制剂. 抑制MCPyV ALTO对默克尔细胞癌的发展至关重要.

关键词:
爱斯坦-巴尔病毒病毒.梅克尔细胞癌瘤是什么?这就是NF-κBB.另一个LT开放阅读框架 (ALTO)这种病毒是多聚马病毒.

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