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Updated: Jun 17, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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通过选择点来设计治疗性附体/PD-L1复合体的机械稳定性

Byeongseon Yang1,2, Diego E B Gomes3, Zhaowei Liu1,2,4

  • 1Institute for Physical Chemistry, Department of Chemistry, University of Basel, 4058 Basel, Switzerland.

bioRxiv : the preprint server for biology
|June 3, 2024
PubMed
概括

像Affibody:PD-L1这样的蛋白质复合物的机械稳定性取决于方向. 优化的点显著提高了复杂的机械稳定性,这对于药物输送应用至关重要.

关键词:
原子力显微镜的原子力显微镜.机械的异质性是机械的异质性蛋白质工程工程 蛋白质工程单分子力光谱法 单分子力光谱法引导了分子动力学.

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相关概念视频

Lipids as Anchors01:32

Lipids as Anchors

In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...