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Updated: Jun 24, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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Published on: January 31, 2018

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一个PARP2特定的活性位点α-螺旋融化,允许DNA损伤诱导的酶激活

Emily S Smith-Pillet1,2, Ramya Billur1, Marie-France Langelier3

  • 1Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute.

bioRxiv : the preprint server for biology
|June 3, 2024
PubMed
概括

聚 (ADP-ribose) 聚合酶1 (PARP1) 和PARP2酶对于DNA修复至关重要,并且是癌症药物的点. 新的研究揭示了PARP1和PARP2之间独特的激活机制和结构差异,影响了药物特异性.

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