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Updated: Jun 24, 2025

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通过与衰老相关的分泌表型,衰老类型的微质限制了复髓化

Phillip S Gross, Violeta Duran Laforet, Zeeba Manavi

    bioRxiv : the preprint server for biology
    |June 3, 2024
    PubMed
    概括

    细胞衰老会损害老化和多发性硬化症 (MS) 中的髓修复. 消除衰老细胞有助于年轻小鼠的复髓化,但不是老年小鼠,这表明了新的治疗点.

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    In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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