母亲西方风格的饮食计划骨肌肉基因表达在瘦的青少年日本子的后代
bioRxiv : the preprint server for biology
|June 3, 2024
概括
母亲的西方风格饮食 (WSD) 显著改变后代的肌肉基因表达,增加代谢疾病的风险. 断奶后的饮食只会影响后代,如果母亲吃了控制饮食,强调母亲的饮食.
科学领域:
- 营养科学 营养科学
- 发展生物学 发展生物学
- 基因组学就是基因组学.
背景情况:
- 孕妇肥胖和怀孕期间的西式饮食 (WSD) 会增加后代患胰岛素抵抗和代谢功能障碍相关的脂肪性肝病 (MASLD) 等代谢疾病的风险.
- 以前的研究表明,母亲的WSD导致骨肌肉线粒体代谢减少,并增加后代的胰岛素抵抗,即使在控制饮食中.
结论:
- 母亲的饮食成分对后代的肌肉转录组有深远而持久的影响.
- 孕产妇的饮食会影响后代对断奶后WSD的转录反应,这可能解释了代谢性疾病易感性增加.
相关概念视频
Genomic Imprinting and Inheritance
34.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.3K
Lethal Alleles
15.4K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.4K


