性变态在组织胺调节的条状多巴胺的性变态
Meghan Van Zandt1, Christopher Pittenger1,2,3,4,5
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA, 06519.
bioRxiv : the preprint server for biology
|June 3, 2024
概括
双胺对雄性和雌性小鼠的影响不同,影响与图雷特综合征 (TS) 和ADHD等神经精神疾病相关的大脑电路.
科学领域:
- 神经科学是一个神经科学.
- 神经药理学神经药理学
- 神经内分泌学神经内分泌学
背景情况:
- 基底质中的多巴胺调节显示了性别差异,并与诸如图雷特综合征 (TS) 和注意力缺陷多动性障碍 (ADHD) 等神经精神疾病有关.
- 基因组胺失调可能导致多巴胺系统功能障碍,特别是在TS.
研究的目的:
- 为了研究条性多巴胺由组胺的性别特异调节.
- 确定特定的组胺受体和大脑区域参与这种性二态调节.
主要方法:
- 在小鼠中进行微透析以测量条纹性多巴胺水平.
- 使用基因素受体agonists和对抗剂的药理学操纵.
- 在特定的神经元群体中,shRNA对基因素受体的敲除.
- 在女性雌性周期的不同阶段监测组胺的作用.
主要成果:
- 在男性中,脑内静脉内组织胺降低了条状多巴胺,这取决于黑色物质的H2受体 (SNc).
- 意想不到的是,在女性中,基因组胺增加了条纹性多巴胺,这种多巴胺由条纹体中的H3受体介导.
- 女性的效果是由雌激素周期调节的,在雌激素水平高的雌激素/雌激素周期期间发生.
结论:
- 海斯胺显著调节带状多巴胺,具有明显的性变态.
- 组胺对多巴胺的调节涉及不同的受体亚型 (男性的H2R,女性的H3R) 和大脑区域 (男性的SNc,女性的条纹体).
- 在雌激素周期期间的雌激素水平会影响雌激素对雌激素对雌激素的影响,从而提供对大脑功能和神经精神疾病的性别差异的见解.
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