增强的动态共价化学,用于从纳米纤维酸水凝平台中控制释放小分子和生物物质
bioRxiv : the preprint server for biology
|June 3, 2024
概括
新的自组装基凝 (SABER MDPs) 能够持续释放药物. 这些水凝扩展了甘菲博洛和胰岛素等药物的治疗效果,改善了感染治疗和糖尿病管理.
科学领域:
- 生物材料科学 生物材料科学
- 药物运输 药物运输 药物运输
- 纳米技术纳米技术
背景情况:
- 保持最佳的药物度是一个持续的临床挑战.
- 多域 (MDPs) 形成具有可用于药物输送的多孔纳米结构的水凝,但受到快速药物扩散的影响.
- 现有的药物输送系统经常在持续释放方面扎,限制了治疗疗效.
研究的目的:
- 开发用于延长药物释放的新型自组装基凝.
- 创建一种能够与药物有效载荷进行动态共价相互作用的药物递送系统.
- 评估这些水凝在延长各种治疗剂活性方面的有效性.
主要方法:
- 自组装酸释放 (SABER) 多域的开发.
- 将含酸 (BA) 的药物,改性胰岛素和抗体纳入SABER水凝中.
- 在体外和体外的药理动力学和疗效研究,包括感染模型和糖尿病小鼠研究.
主要成果:
- SABER水凝成功延长了五种小分子药物,改性胰岛素和含酸的抗体的释放.
- 药理动力学研究表明,甘菲博的治疗效果从几天延长到几周,在感染模型中表现优于重复口服.
- 在一次注射改性胰岛素后,SABER水凝在糖尿病小鼠中维持了6天的血糖正常.
结论:
- 与传统方法相比,SABER 水凝显著提高药物释放时间.
- 该技术在感染模型中表现出卓越的疗效,并在糖尿病小鼠中维持正常血糖.
- 在药物药物输送中,SABER 水凝具有广泛的临床转化潜力.
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