鼻中的微生物组:关于COVID-19严重程度影响的见解
David Galeana-Cadena1,2, Gustavo Ramirez-Martínez1, José Alberto Choreño-Parra1
1Laboratorio de Inmunobiología y Genética, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City, Mexico.
Heliyon
|June 3, 2024
概括
COVID-19的严重程度与鼻微生物组的显著变化有关. 危急病患者的Lawsonella和Cutibacterium减少,口腔细菌增加,例如Streptococcus.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 呼吸道拥有多样化的微生物群,受其位置,环境和健康状况的影响.
- 了解鼻微生物组在COVID-19中的作用对于疾病管理至关重要.
研究的目的:
- 为了调查COVID-19严重程度与鼻微生物组组成之间的关联.
- 为了确定与COVID-19患者的严重疾病相关的特定微生物转变.
主要方法:
- 一项前性队列研究,涉及30名COVID-19患者和14名墨西哥城的健康对照.
- 用16S rRNA基因测序进行微生物组概况分析,分析了鼻拭子.
- 使用R包进行了统计分析,包括多样性和核心微生物组评估.
主要成果:
- 在严重的COVID-19病例中观察到鼻微生物组的显著分类学变化.
- 危急病患者在Lawsonella和Cutibacterium属中显著减少 (p < 0.001).
- 口腔细菌的丰富,包括Streptococcus和Actinomyces,在严重的COVID-19患者中是突出的 (p <0.01).
结论:
- 在严重的COVID-19中,鼻微生物组的破坏可能是炎症过程和输管的结果.
- 变化表明,改变的条件有助于口腔微生物在重症患者的殖民.
- 这些发现突出了严重的COVID-19中潜在的微生物生物标志物和治疗点.
关键词:
在 COVID-19 疫情中,科里尼细菌 (Corynebacterium) 是一种细菌昆虫细菌的核心微生物组输入管道是为了输入管道.律师事务所 (Lawsonella) 是一个法律事务所.鼻喉微生物组 鼻喉微生物组鼻和鼻 (Nasopharynx) 是一个鼻和鼻.这种病原体是葡萄球菌.链球菌是一种链球菌.更多相关视频
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