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免疫细胞与乳腺癌风险之间的因果关系和代谢物媒介:孟德尔的随机化研究

Ruijie Ming¹, Huan Wu², Hong Liu³

¹Department of Oncology, Chongqing University Three Gorges Hospital, Chongqing, China.

Frontiers in genetics

|June 3, 2024

概括

这项研究表明,特定的血液免疫细胞,如IgD-CD38+B细胞,因果关系影响乳腺癌风险. 这些B细胞通过与代谢物甘酸和苏奇诺氨酸的相互作用增加了乳腺癌的风险.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

在全球范围内,乳腺癌发病率和死亡率仍然很高.
乳腺癌中观察到瘤免疫微环境的显著变化.
血液免疫细胞水平对乳腺癌风险的因果影响需要进一步调查.

研究的目的:

研究血液免疫细胞水平与乳腺癌风险之间的因果关系.
探索这种关系中的潜在调解因素,包括代谢物.

主要方法:

进行了两样本的门德尔随机化 (MR) 分析.
免疫细胞和乳腺癌的遗传数据来自GWAS目录和英国生物银行.
逆变量加权 (IVW) 方法用于评估因果关系,并对代谢物进行中介分析.

主要成果:

基因预测的CD24+CD27+B细胞显示乳腺癌的风险降低 (OR=0.9978,p=0.001).
抗原体-CD38+B细胞 (OR=1.002,p=0.005) 和CD14+CD16+单细胞 (OR=1.000,p=0.005) 与乳腺癌风险增加有关.
IgD-CD38+B细胞通过糖酸盐 (阳性) 和糖酸 (阴性) 水平调解了乳腺癌风险.

结论:

这项MR研究提供了新的遗传证据,证明IgD-CD38+B细胞与乳腺癌 (BC) 风险之间存在因果关系.
IgD-CD38+ B 细胞通过涉及甘油酸和氨酸氨酸的调解效应,有助于增加BC风险.
了解这些免疫细胞-代谢物相互作用可能为BC预防和治疗提供新的途径.

关键词:

门德尔的随机化研究.乳腺癌乳腺癌乳腺癌因果关系影响因果关系影响.免疫细胞是免疫细胞.代谢物介导体的代谢物

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